Htr2c Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comHtr2c Polyclonal Antibody for Mouse(Mus musculus)

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Htr2c (Gene name),

5-hydroxytryptamine receptor 2C (Protein name ), 5HT2C_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Htr2c(5ht1c;Htr1c);

Protein name:

5-hydroxytryptamine receptor 2C(5-HT-2C;5-HT2C;5-HTR2C);

Alternative:

Serotonin receptor 2C;5-hydroxytryptamine receptor 1C(5-HT-1C;5-HT1C);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with MPDZ. Interacts with ARRB2.

Function:

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Subcellular Location:

Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

459

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

459:

VVSERISSV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P34968

UniGene:

Mm.439670

Pfam:

PF00001

KEGG:

mmu:15560

SMR:

P34968

Uniprot:

P34968

FOR

ELISA Kit for Mouse 5-HT-2C

Cat.:

E10285r

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Mouse 5-HT-2C

Cat.:

E10285m

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MSDS:

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Packing:

96T

ELISA Kit for Mouse 5-HT-2C

Cat.:

E10285h

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MSDS:

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Packing:

96T

ELISA Kit for Mouse 5-HT-2C

Cat.:

E10285d

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MSDS:

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Packing:

96T

CLIA Kit for Mouse 5-HT-2C

Cat.:

U10285r

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MSDS:

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Packing:

96T

CLIA Kit for Mouse 5-HT-2C

Cat.:

U10285m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse 5-HT-2C

Cat.:

U10285h

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MSDS:

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Packing:

96T

CLIA Kit for Mouse 5-HT-2C

Cat.:

U10285d

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse 5-HT-2C

Cat.:

P10285Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse 5-HT-2C

Cat.:

P10285Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse 5-HT-2C

Cat.:

P10285Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse 5-HT-2C

Protein for Mouse 5-HT-2C

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The mouse 5-HT1C receptor contains eight hydrophobic domains and is X-linked."
Yu L. , Nguyen H. , Le H. , Bloem L.J. , Kozak C.A. , Hoffman B.J. , Snutch T.P. , Lester H.A. , Davidson N. , Luebbert H.
Brain Res. Mol. Brain Res.11:143-149(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Structure of the mouse 5-HT1C, 5-HT2 and stomach fundus serotonin receptor genes."
Foguet M. , Nguyen H. , Le H. , Luebbert H.
NeuroReport3:345-348(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
4.

"Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors."
Tecott L.H. , Sun L.M. , Akana S.F. , Strack A.M. , Lowenstein D.H. , Dallman M.F. , Julius D.
Nature374:542-546(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION;TISSUE SPECIFICITY
5.

"Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene."
Nonogaki K. , Strack A.M. , Dallman M.F. , Tecott L.H.
Nat. Med.4:1152-1156(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
6.

"Serotonin 5-HT(2C) receptors regulate anxiety-like behavior."
Heisler L.K. , Zhou L. , Bajwa P. , Hsu J. , Tecott L.H.
Genes Brain Behav.6:491-496(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
7.

"Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation."
Heisler L.K. , Pronchuk N. , Nonogaki K. , Zhou L. , Raber J. , Tung L. , Yeo G.S. , O'Rahilly S. , Colmers W.F. , Elmquist J.K. , Tecott L.H.
J. Neurosci.27:6956-6964(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION;TISSUE SPECIFICITY
8.

"5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis."
Xu Y. , Jones J.E. , Kohno D. , Williams K.W. , Lee C.E. , Choi M.J. , Anderson J.G. , Heisler L.K. , Zigman J.M. , Lowell B.B. , Elmquist J.K.
Neuron60:582-589(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION;TISSUE SPECIFICITY
9.

"Characterizing the effects of 5-HT(2C) receptor ligands on motor activity and feeding behaviour in 5-HT(2C) receptor knockout mice."
Fletcher P.J. , Tampakeras M. , Sinyard J. , Slassi A. , Isaac M. , Higgins G.A.
Neuropharmacology57:259-267(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
10.

"A serotonin and melanocortin circuit mediates D-fenfluramine anorexia."
Xu Y. , Jones J.E. , Lauzon D.A. , Anderson J.G. , Balthasar N. , Heisler L.K. , Zinn A.R. , Lowell B.B. , Elmquist J.K.
J. Neurosci.30:14630-14634(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
11.

"5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver."
Xu Y. , Berglund E.D. , Sohn J.W. , Holland W.L. , Chuang J.C. , Fukuda M. , Rossi J. , Williams K.W. , Jones J.E. , Zigman J.M. , Lowell B.B. , Scherer P.E. , Elmquist J.K.
Nat. Neurosci.13:1457-1459(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
12.

"Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels."
Sohn J.W. , Xu Y. , Jones J.E. , Wickman K. , Williams K.W. , Elmquist J.K.
Neuron71:488-497(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION

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